In 1987 Esaote SpA began marketing its products in the United States through Biosound Inc.. In 1990 Esaote SpA acquired Biosound Inc.. Biosound Esaote today also distributes the veterinarian derivates from Esaote Pie Medical in the United States.

'BIOSOUND ESAOTE is an ISO9001/EN46001 certified major medical corporation operating as part of the international Esaote Group. With its parent company, Esaote, S.p.A. based in Genoa, Italy, ISO-9000 certified research and development and manufacturing facilities in Florence and Genoa, and North American headquarters in Indianapolis, the Esaote Group develops diagnostic ultrasound and magnetic resonance imaging (MRI) equipment for the worldwide medical community.'

Ultrasound Related Product Lines:

Ultrasound Systems:

(HIFU / FUS) High intensity focused ultrasound is used in thermotherapy or thermoablation e.g., for the treatment of benign prostate hyperplasia or under study for the treatment of cancer.
An applied ultrasound probe (see transrectal sonography) focuses sound waves at one spot, elevating the tissue temperature to a point that the tissue destroys. Generally, lower frequencies (from 250 kHz to 2000 kHz) are used than for medical diagnostic ultrasound, but significantly higher time-averaged intensities.

See also Magnetic Resonance Guided Focused Ultrasound, Low Intensity Pulsed Ultrasound, and Lithotripsy.

In June 2007 Tyco International Ltd. completed the separation of its healthcare business, which is named Covidien. Mallinckrodt, Inc. is now part of Covidien Ltd. The company makes and distributes products for respiratory care; bulk and dosage pharmaceuticals, primarily for pain relief and addiction therapy; and imaging agents for magnetic resonance, ultrasound, x-ray, and nuclear medicine applications. With worldwide manufacturing and distribution facilities and sales offices, Mallinckrodt, Inc. sells its products worldwide.
Albunex was one of the first marketed ultrasound contrast agents. Currently, Mallinckrodt discontinued the manufacturing and development of ultrasound contrast agents.

Ultrasound Contrast Agents:

Molecular Biosystems, Inc. (MBI), founded in 1980, is a biomedical company developing a range of contrast agents for use with diagnostic ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT).
Alliance Pharmaceutical Corp. acquires Molecular Biosystems in Nov. 2000.

Quadrature detection is used in Doppler ultrasound as well as in magnetic resonance imaging and is also called quadrature demodulation or phase quadrature technique. Quadrature detection is the acquisition of Mx and My simultaneously as a function of time by using two separate detector channels. This signal processing method is used for directional Doppler in which the signal reference frequency for the two channels has a phase shift of 1/4 period. The output Doppler signal phase for both channels also depends on the Doppler shift whether positive or negative.
The fast Fourier transform analyzer performs spectral Doppler analysis in ultrasound machines and displays different quadrature Doppler frequencies, when a sample volume cursor is used along time.