Plethysmography implies volume measurement procedures including air, impedance or strain gauge methods. Vascular plethysmography is a non-invasive measurement of the systolic blood pressure of a leg compared with that of an arm to determine circulatory capacity. The test is usually performed to rule out vascular blockages in the arms or legs, usually in combination with Doppler ultrasound.

See also Oculoplethysmography, and Pulse Volume Recording.

A flat velocity profile in large vessels is termed plug flow, indicating that all or most of the blood is flowing at a single velocity per time unit.

See also Blood Flow Velocity.

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'POINT Biomedical was a privately held pharmaceutical company, founded in 1996 to pursue technologies related to imaging and drug delivery. POINT's core technology was based upon an ultrasonically responsive two-layer, biodegradable microsphere or BiSphere™. One of the most important features of this technology is the ability to noninvasively trigger the BiSpheres™ to release their contents at sites within the body using externally generated pulses of ultrasound. From this basic platform, POINT was developing a pipeline of products that leverage the unique properties of the BiSphere™ technology in the areas of imaging and therapeutics. POINT has initially focused development of this platform on the assessment of tissue specific blood flow. The lead product, CARDIOsphere®, is a pharmaceutical agent that will enable cardiologists to perform myocardial perfusion imaging studies in the office setting using ultrasound rather than more expensive and cumbersome nuclear medicine (or radioisotope) techniques.'
'According to BioSpace, Tom Feldman, ex-CEO of Point BioMedical, the company's lead investor, Vendanta Capital has chosen not to follow through with the second half of its $50 million private equity financing. Point BioMedical has withdrawn the new drug application for its molecular imaging agent CARDIOsphere and is liquidating its assets to avoid a formal bankruptcy proceeding in 2008.'

A point scatterer is a reflector with a diameter much smaller than the ultrasound wavelength. The reflection from blood is a typical example of point scattering. Red blood cells are with 7μm versus 0.44 mm wavelength at 3.5 MHz, smaller than any US wavelength. The individual cells are not only the point scatterers, ultrasound is scattered whenever there is a change in acoustic impedance, and in blood such changes are caused by variable cell concentration. These local fluctuations in cell concentration have a spatial extent that is also much smaller than the ultrasound wavelength, and they therefore act as point scatterers.
A point scatterer gives rise to spherical wavelets spreading out in all directions with the scatterer itself at the center of the sphere. The spherical wavelets from one single point scatterer are much too weak to be detected by the transducer, but constructive interference between numerous wavelets will produce backscattering of higher amplitude echoes with parallel wavefronts, also in the direction of the ultrasound transducer.

See also Rayleigh Scattering.

Poiseulles law states that the flow rate in a long, straight tube with laminar flow is proportional to its length and viscosity and inversely proportional to the fourth power of its radius.

See also Proportionality Constant.