Medical Ultrasound Imaging
Thursday, 31 October 2024
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Searchterm 'In Phase' found in 24 articles
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Acusphere, Inc.
www.acusphere.com [This entry is marked for removal.]

'Acusphere (NASDAQ:ACUS) was a specialty pharmaceutical company that develops new drugs and improved formulations of existing drugs using its proprietary microparticle technology. Acusphere's three initial product candidates are designed to address large unmet clinical needs within cardiology, oncology and asthma. These product candidates were created using proprietary technology that enables Acusphere to control the porosity and size of nanoparticles and microparticles in a versatile manner that allows particles to be customized to address the delivery needs of a variety of drugs. Acusphere's lead product candidate, AI-700 (new trade name Imagify™), is a cardiovascular drug in Phase 3 clinical development. AI-700 is designed to enable ultrasound to compete more effectively with nuclear stress testing, the leading procedure for detecting coronary heart disease. An estimated 9.5 million procedures are done each year in the U.S. to detect coronary heart disease, the leading cause of death in the United States.'

In 2008 the FDA panel rejected the regulatory application for AI-700 (Imagify™) because of safety concerns.

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Coherence
Coherence is the degree of phase agreement among waves. A coherent sound wave is one in which all of the signals are in phase.
Contrast Pulse Sequencing
(CPS) Contrast pulse sequencing is a technique to exploit contrast agent properties with series of three pulses that differ in phase and amplitude. CPS allows bubble specific imaging with non-linear fundamental and higher order harmonics, low MI, and extremely high microbubble-to-tissue background ratio.

See also Ultrasound Contrast Agent Safety.
Focus
In contrast enhanced ultrasound, the focus is the point at which maximum bubble destruction occur.
The transmit focus is the region on the axis of an ultrasound beam where the width of the beam has a minimum value. All waves crossing the focus are in phase in relation to the transducer surface or to the electronic summing point of an electronically focused array.
Interference
Interference is the interplay of two or more waveforms. When two or more waves with equal frequency and wavelength interfere, a new wave is created whose amplitude at any point in time and space is the sum of the amplitudes of the original waves at the same point in time and space. Constructive interference occurs when two waves of equal frequency are in phase. The amplitudes will always be in the same direction, and the waves will combine to produce a stronger one. Two equally strong waves with the same amplitude that are 180° out of phase will cancel each other out.

See also Interference Artifact.
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