Medical Ultrasound Imaging
Saturday, 27 April 2024
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(AALs) Acoustically active lipospheres and ultrasound are under development to deliver bioactive molecules to the vascular endothelium. The AALs are similar to both ultrasound contrast agents and drug-delivering liposomes. They can carry bioactive substances using biologically inert shells and deliver those substances when disrupted by ultrasound. The lipospheres consist of a small gas microbubble surrounded by a thick oil shell and are enclosed by an outermost lipid layer. The gas bubble contained in these vehicles makes them acoustically active, similar to ultrasound contrast agents. Acoustically active lipospheres can be nondestructively deflected using ultrasound radiation force, and fragmented with high intensity ultrasound pulses. Their lipid-oil complex can carry bioactive substances at high concentrations. An optimized sequence of ultrasound pulses can deflect the AALs toward a vessel wall then disrupt them, painting their contents across the vascular endothelium. See also Filling Gas, and MRX 115.  Further Reading: Basics:
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(CAP) Contrast agent particles are filled with gas and coated by a shell. The reflectivity of a particle increases with the diameter. The used particles are too large to cross the endothelium, so that there is no interstitial phase of enhancement. They are essentially markers for the blood pool and their distribution is similar to those of tagged red cells. In addition, any body cavity that can be accessed can be injected with vascular contrast.
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SonoGen (QW7437) is an anionically charged 2% perfluorocarbon emulsion under development as a transpulmonary myocardial ultrasound contrast agent (UCA). The SonoGen microbubbles have a reduced adherence to the negatively charged vascular endothelium and reduced coalescence. SonoGen, a second generation USCA has the theoretical potential to provide high safety and efficacy and improved tissue grayscale persistence compared to first generation fluorocarbon contrast agents.
Drug Information and Specification
RESEARCH NAME
DEVELOPER
INDICATION -
DEVELOPMENT STAGE Echocardiography - Phase 1
APPLICATION
Intravenous injection
TYPE
Microbubble
Surfactant
CHARGE
Negative
Dodecafluoropentane
MICROBUBBLE SIZE
-
PREPARATION
-
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[last update: 2023-11-06 01:42:00]