Medical Ultrasound Imaging
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CARDIOsphere®
[This entry is marked for removal.]

From POINT Biomedical Corp
CARDIOsphere® is an ultrasound contrast agent for assessment of myocardial perfusion in patients with coronary artery disease composed of highly echogenic bispheres.
PB127 is a new developed microbubble with a bilayer polymer/albumin shell filled with nitrogen gas that has ideal characteristics for power harmonic Doppler. They can be destroyed by high power ultrasound, and spectral decorrelation between ultrasound pulses is maximized by rapid dissolution of the released nitrogen gas.
POINT Biomedical Corp. announced (March 01, 2004) that it has completed two Phase 3 trials of CARDIOsphere®. The Phase 3 trials were designed to evaluate the performance of CARDIOsphere® imaging relative to radionuclide imaging for detecting obstructive coronary artery disease and identifying the anatomic location of perfusion defects.
Drug Information and Specification
RESEARCH NAME
PB 127
DEVELOPER
Point Biomedical Corp.
INDICATION -
DEVELOPMENT STAGE
Myocardial perfusion -
Phase 3 completed
APPLICATION
Infusion
TYPE
Microbubble
SHELL
Polylactide/Albumin
CHARGE
Slight Negative
GAS
Nitrogen
PREPARATION
Reconstitute with 2ml H2O per vial and dilute with 150 ml DSW
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
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CTS-200
www.siui.com/english/product/200.htm From SIUI Inc.;
'The SIUI CTS-200 is one of few 'linear only' units to be developed with a digital scan converter to process all incoming signals. With a digital processor, not only is the incoming signal processed faster but less noise is introduced into the signal path. The images are cleaner, crisper than you have experienced, even in machines at many times the price.'
'CTS-200 is suitable to a wide range of examination of liver, gallbladder, kidney, spleen, pancreas, thyroid gland, breast, uterus, urinary bladder, OB/GYN, etc. It is a portable ultrasound scanner of high performance.'

Device Information and Specification
APPLICATIONS
See description above
CONFIGURATION
Portable, gray scale(256)
TRANSDUCERS
Linear
PROBES STANDARD
1 * 3.5MHz Linear Probe EZU-PL21
PROBES FREQUENCY
3.5MHz, 7.5MHz
IMAGING MODES
B-mode,B/M, M-mode,B+B mode
IMAGING OPTIONS
*1, *1.5, *2 as well as depth shift
OPTIONAL PACKAGE
7.5MHz Linear Probe EZU-PL23; 7.5MHz Transrectal Probe EUP-U23; 3.5MHz Biopsy Probe EUP-B11A; Trolley/Mobile Cart; ...
DATA PROCESSING
Pre-processing, correlation-processing, interpolation
POWER REQUIREMENT
AC 220V/110V, 50Hz/60Hz
POWER CONSUMPTION
0.05 KVA
  Further Reading:
Basics:
  • CTS-200
       by www.accessdata.fda.gov    
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