From Bayer Schering Pharma AG:
Available in Europe since 1996 and in Japan since 1999. Currently, the marketing situation is unclear.
Levovist® is a first generation USCA consisting of galactose (milk sugar) ground into tiny crystals whose irregular surfaces act as nidation sites on which air pockets form when it is suspended in water, much as soda water bubbles form at small irregularities on the surface of the glass. A trace of palmitic acid is added as a surfactant to stabilize the resultant microbubbles. When Levovist® dissolves in blood, air trapped inside the galactose is released as free gas bubbles. These bubbles have a weak encapsulating shell and are easily destroyed by ultrasound.
Different contrast ultrasonography methods have been developed since the introduction of Levovist®. Initially, Levovist® was an echo contrast medium for improving sensitivity in color Doppler and Power Doppler examinations, but was found to suffer from significant blooming, making it difficult to observe small blood vessels. However, Levovist® improves the accuracy of echocardiographic examinations in such indications as assessment of left ventricular function.
In addition to their vascular phase, some ultrasound contrast agents (USCAs) can exhibit a tissue- or organ-specific phase. Levovist® can accumulate within the liver and the spleen for up to 20 min once it has disappeared from the blood pool and improves the detectability of focal liver lesions and allows more reliable control of interventional tumor treatments. Varied types of information can be obtained by applying contrast imaging at different times after the injection using Levovist® in both the arterial phase and the late organ-specific phase.
1 g Levovist® granules contain 999 mg D-galactose and 1 mg palmitic acid.
Brand names in other countries: Levovist/Levograf

The line density describes the number of acoustic scan lines per sector in a 2D black and white or color sector image.

Linear array transducer elements are rectangular and arranged in a line. Linear array probes are described by the radius of width in mm. A linear array transducer can have up to 512 elements spaced over 75-120 mm. The beam produced by such a narrow element will diverge rapidly after the wave travels only a few millimeters. The smaller the face of the transducer, the more divergent is the beam. This would result in poor lateral resolution due to beam divergence and low sensitivity due to the small element size.
In order to overcome this, adjacent elements are pulsed simultaneously (typically 8 to 16; or more in wide-aperture designs). In a subgroup of x elements, the inner elements pulse delayed with respect to the outer elements. The interference of the x small divergent wavelets produces a focused beam. The delay time determines the depth of focus for the transmitted beam and can be changed during scanning.
Linear arrays are usually cheaper than sector scanners but have greater skin contact and therefore make it difficult to reach organs between ribs such as the heart. One-dimensional linear array transducers may have dynamic, electronic focusing providing a narrow ultrasound beam in the image plane. In the z-plane (elevation plane - perpendicular to the image plane) focusing may be provided by an acoustic lens with a fixed focal zone.
Rectangular or matrix transducers with unequal rows of transducer elements are two-dimensional (2D), but they are termed 1.5D, because the number of rows is much less than the number of columns. These transducers provide dynamic, electronic focusing even in the z-plane.

See also Rectangular Array Transducer.

A linear probe contains one or more acoustic linear array transducer elements arranged in a line to send pulses of sound into a material. The linear array gives a large probe surface (footprint) and near field. In Doppler mode, a linear probe operates a subset of its elements as a linear phased array and can thus steer the Doppler beam at a selected angle to the imaging beam. This is a popular configuration for peripheral vascular and perivascular scanning.

Linear scattering occur from specular reflectors or tissue, in which the echo is an accurate copy of the incident ultrasound pulse. If the phase or amplitude of the transmitted sound is altered, the phase or amplitude of the echo will be also altered.
Non-linear scatterers, such as microbubbles, do not follow these rules.