From Siemens Medical Systems;
'Conventional ultrasound systems are unable to compensate for the unique acoustic signature of individual patients. But there is nothing conventional about the new ACUSON Sequoia™ C512 echocardiography system with Sequoia™ matched response technology.'

From Siemens Medical Systems;
'The Acuson Sequoia™ ultrasound system's unique use of ultrasound physics will allow you to see aspects of anatomy and physiology like never before. Its unrivaled performance is based on four technology cornerstones. To understand these technologies is to appreciate just how far this platform has advanced the science of ultrasound.'

Specifications for this system will be available soon.

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'Acusphere (NASDAQ:ACUS) was a specialty pharmaceutical company that develops new drugs and improved formulations of existing drugs using its proprietary microparticle technology. Acusphere's three initial product candidates are designed to address large unmet clinical needs within cardiology, oncology and asthma. These product candidates were created using proprietary technology that enables Acusphere to control the porosity and size of nanoparticles and microparticles in a versatile manner that allows particles to be customized to address the delivery needs of a variety of drugs. Acusphere's lead product candidate, AI-700 (new trade name Imagify™), is a cardiovascular drug in Phase 3 clinical development. AI-700 is designed to enable ultrasound to compete more effectively with nuclear stress testing, the leading procedure for detecting coronary heart disease. An estimated 9.5 million procedures are done each year in the U.S. to detect coronary heart disease, the leading cause of death in the United States.'

In 2008 the FDA panel rejected the regulatory application for AI-700 (Imagify™) because of safety concerns.

Three tissue layers called tunicae, or coats, surround the lumen of an artery. The adventitia (outer coat) is the outermost layer of an arterial wall and is composed of connective tissue containing elastic fibers and another layer of protein called the external basement membrane.
Smooth muscle cells comprise the tunica media, or middle coat. The muscle cells contract or relax to constrict or dilate the artery.

Any abnormal reaction of a patient to an examination or procedure, like for example side effects of contrast agents or claustrophobia. Claustrophobic attacks as can happen with MRI are unknown with ultrasound examinations. Adverse reactions with ultrasonic contrast agents are very infrequent. In general, adverse reactions increase with the quantity of contrast media and also with the osmolarity of the compound.
Most frequently encountered adverse reactions are: Heat sensation, dizziness, nausea, hypotension due to vasodilatation, which can progress to hypotensive shock and anaphylactic reactions.