Medical Ultrasound Imaging
Thursday, 9 May 2024
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(CCI) A major limitation of the use of ultrasound contrast agents is the problem that signals from the microbubbles are mixed with those from tissue, so that the distribution of the microbubbles is not optimally displayed either in Doppler or gray scale. Coherent contrast imaging is a high frame rate implementation of inverting the phase of alternate sound pulses and summing the resulting echoes. The symmetrical signals from linear reflectors are cancelled leaving those from non-linear scatterers, with the advantage that the cancellation is performed without the need to transmit two pulses per image line so that bubble destruction is minimized. Coherent contrast imaging yields best results in the vascular phase of phospholipid microbubbles (such as Definity and SonoVue). See also Coherence. •
(PII) Pulse inversion imaging (also called phase inversion imaging) is a non-linear imaging method specifically made for enhanced detection of microbubble ultrasound contrast agents. In PII, two pulses are sent in rapid succession into the tissue; the second pulse is a mirror image of the first. The resulting echoes are added at reception. Linear scattering of the two pulses will give two echoes which are inverted copies of each other, and these echoes will therefore cancel out when added. Linear scattering dominates in tissues. Echoes from linear scatterers such as tissue cancel, whereas those from gas microbubbles do not. Non-linear scattering of the two pulses will give two echoes which do not cancel out completely due to different bubble response to positive and negative pressures of equal magnitude. The harmonic components add, and the signal intensity difference between non-linear and linear scatterers is therefore increased. The resulting images show high sensitivity to bubbles at the resolution of a conventional image. In harmonic imaging, the frequency range of the transmitted pulse and the received signal should not overlap, but this restriction is less in pulse inversion imaging since the transmit frequencies are not filtered out, but rather subtracted. Broader transmit and receive bandwidths are therefore allowed, giving shorter pulses and improved axial resolution, hence the alternative term wideband harmonic imaging. Many ultrasound machines offer some form of pulse inversion imaging. See also Pulse Inversion Doppler, Narrow Bandwidth, Dead Zone, Ultrasound Phantom. •
Speckle noise affects the quality of the ultrasound images and can mask pathology. This artifact can be reduced by using a phase insensitive technique, or by canceling the undesirable linear-phase representation. More system samplings (needs more channels and memory) or a fuzzy logic algorithm can filter out the speckle noise.
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Tissue-specific ultrasound contrast agents improve the image contrast resolution through differential uptake. The concentration of microbubble contrast agents within the vasculature, reticulo-endothelial, or lymphatic systems produces an effective passive targeting of these areas. Other contrast media concepts include targeted drug delivery via contrast microbubbles. Tissue-specific ultrasound contrast agents are injected intravenously and taken up by specific tissues or they adhere to specific targets such as venous thrombosis. These effects may require minutes to several hours to reach maximum effectiveness. By enhancing the acoustic differences between normal and diseased tissues, these tissue-specific agents improve the detectability of abnormalities. Some microbubbles accumulate in normal hepatic tissue; some are phagocytosed by Kupffer cells in the reticuloendothelial system and others may stay in the sinusoids. Liver tumors without normal Kupffer cells can be identified by the lack of the typical mosaic color pattern of the induced acoustic emission. The hepatic parenchymal phase, which may last from less than an hour to several days, depending on the specific contrast medium used, may be imaged by bubble-specific modes such as stimulated acoustic emission (color Doppler using high MI) or pulse inversion imaging.  Further Reading: News & More:
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Transducers used for the real-time mode are different than for the A-mode, B-, or M-modes. A linear array transducer with multiple piezoelectric crystal elements that are different arranged and fired, transmits the needed larger sound beam. A subgroup of x adjacent elements (8-16; or more in wide-aperture designs) is pulsed simultaneously; the inner elements pulse delayed with respect to the outer elements. The interference of the x small divergent wavelets generates a focused beam. The delay time determining the focus depth of a real-time transducer can be changed during imaging. Similar delay factors applied during the receiving phase, result in a dynamic focusing effect on the return. This forms a single scan line in the real-time image. To produce the following scan line, another group of x elements is selected by shifting one element position along the transducer array from the previous group. This pattern is then repeated for the groups along the array, in a sequential and repetitive way. Further Reading: Basics: Result Pages : | Share This Page     Look Ups |
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