Interference artifacts occur if decreasing of the echo amplitude is not exponential with penetration depth caused by inhomogeneous tissue layers and fluid or air-filled regions. If ultrasound waves have opposite phases, i.e. if the phase difference is 180°, their amplitudes will always be in opposite directions and their sum is a weaker wave. This is destructive interference and artifacts occur.

Lateral resolution is the minimum separation of two interfaces aligned along a direction perpendicular (objects that are side by side) to the ultrasound beam. The lateral or angular resolution directly relates with the collimation of the beam emitted by the crystal. Lateral resolution is proportionally affected by the frequency, the higher the frequency the greater the lateral resolution.
Higher frequency transducers are used in fetal and pediatric echocardiography because the lateral resolution displays the smaller structures better. Lower frequencies are used for adults where structures are larger and the need for greater depth penetration is important.

A liver sonography is a diagnostic tool to image the liver and adjoining upper abdominal organs such as the gallbladder, spleen, and pancreas. Deeper structures such as liver and pancreas are imaged at a lower frequency 1-6 MHz with lower axial and lateral resolution but greater penetration. The diagnostic capabilities in this area can be limited by gas in the bowel scattering the sound waves.
The application of microbubbles may be useful for detection of liver lesions and for lesion characterization. Some microbubbles have a liver-specific post vascular phase where they appear to be taken up by the reticuloendothelial system (RES). Dynamic contrast enhanced scans in a similar way as with CT or MRI can be used to studying the arterial, venous and tissue phase.
After a bolus injection, early vascular enhancement is seen at around 30sec in arterialized lesions (e.g., hepatocellular carcinomas (HCC), focal nodular hyperplasia (FNH)). Later enhancement is typical of hemangiomas with gradually filling towards the center. In the late phase at around 90sec, HCCs appear as defects against the liver background. Most metastases are relatively hypovascular and so do not show much enhancement and are seen as signal voids in the different phases.
Either with an intermittent imaging technique or by continuous scanning in a nondestructive, low power mode, characteristic time patterns can be used to differentiate lesions.

See also Medical Imaging, B-Mode, High Intensity Focused Ultrasound, Ultrasound Safety and Contrast Medium.

The skinline is the ultrasonic penetration depth corresponding to the skin / transducer interface on the display.

(TCCS) Transcranial color coded sonography is a combination of B-mode and pulsed wave Doppler. TCCS is used to study morphological and functional assessment of the circle of Willis, intracranial hemodynamics caused by extracranial artery stenosis, collateral flow and the vascular supply of intracranial lesion. Color imaging of the intracranial vessels allows placing the spectral Doppler volume correctly. This modality has encouraged the widespread use.
Contrast enhanced TCCS analysis of cerebral arteriovenous transit time (cTT) is used as a measure of cerebral microcirculation.
The windows that are used for transcranial Doppler examinations include regions where the skull bones are relatively thin or where naturally occurring gaps allow proper penetration of the sound beam.

See also A-Mode, Cranial Bone Thermal Index, Transcranial Doppler and Transcranial Window.